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Dr Frédéric ROBERT
Dr ROBERT Frédéric

CNRS Research Associate
Ph. D. in Organic Chemistry

Phone +33 540006441

CURRENT RESEARCH INTERESTS
- Synthesis of Alkaloids.
- Multicomponent Radical Reactions.
- Organocatalysis.

- Theoretical calculations of reaction mechanims.

EDUCATION

Since october 2002 Research Associate in the group

2001-02 Post-Doc with Pr. E. Peter Kündig at the University Science II, Geneva, Switzerland.
"Elaboration of Ruthenium-based Lewis acids for catalytic asymmetric Diels-Alder reactions".

2000-01 Post-Doc with Pr Peter A. Jacobi at Dartmouth College (New Hampshire, USA).
"First Total Synthesis of Bacteriochlorins used for Photodynamic Therapy (PDT)" (NIH Grant).

1996-99 Ph.D. thesis in organic chemistry at the University Joseph Fourier, Grenoble, France under the direction of Dr Andrew E. Greene.
"A New Approach to the Intermolecular Asymmetric Pauson-Khand Reaction".

1995-96 Master of Science in Molecular Chemistry at the University Joseph Fourier, Grenoble, France.
"Approach to the Total Synthesis of hypoxyxylerone, a Pentacyclic Aromatic Natural Product with Topoisomerase I Inhibiting Activity".

1993-94 Bachelor of Science at the University Joseph Fourier, Grenoble, France (specialization: organic chemistry).
"Enantioselective Synthesis of Taxol and Taxotere side-chains".

Publications

47 - Free-radical Carbo-cyanation of Olefins.
H. Hassan, V. Pirenne, M. Wissing, C. Khiar, A. Hussain, F. Robert, Y. Landais, Chem. Eur. J. 2017, in press.
DOI: 10.1002/chem.201605946

46 - Organic Lewis Pairs Based on Phosphine and Electrophilic Silane for the Direct and Controlled Polymerization of Methyl Methacrylate: Experimental and Theoretical Investigations.
W. Nzahou Ottou, E. Conde-Mendizabal, A. Pascual, A.-L. Wirotius, D. Bourichon, J. Vignolle, F. Robert, Y. Landais, J.-M. Sotiropoulos, K. Miqueu, Daniel Taton, Macromolecules 2017, 50, 762–774.
DOI: 10.1021/acs.macromol.6b02205

45 - Free-radical Carbo-alkenylation of Olefins. Scope, Limitations and Mechanistic Insights.
R. Beniazza, V. Liautard, C. Poittevin, B. Ovadia, S. Mohammed, F. Robert, Y. Landais, Chem. Eur. J. 2017, 23, 2439-2447.
DOI: 10.1002/chem.201605043

44 - Free-Radical Carbocyanation of Cyclopropenes: Stereocontrolled Access to All-Carbon Quaternary Stereocenters in Acyclic Systems.
N. S. Dange, F. Robert, Y. Landais, Org. Lett. 2016, 18, 6156-6159..
DOI: 10.1021/acs.orglett.6b03163

43 - Free-radical Carbo-functionalization of olefins using sulfonyl derivatives.
B. Ovadia, F. Robert, Y. Landais, Chimia 2016, 70, 34-42.
DOI:10.2533/chimia.2016.34

42 - Total Synthesis of (+/-)-Eucophylline. A Free-radical Approach to the Synthesis of the Azabicyclo[3.3.1]nonane Skeleton.
H. Hassan, S. Mohammed, F. Robert, Y. Landais, Org. Lett. 2015, 17, 4518-4521.
DOI: 10.1021/acs.orglett.5b02218

41 - Chiral Memory in Silylium Ions.
P. Ducos, V. Liautard, F. Robert, Y. Landais, Chem. Eur. J. 2015, 21, 11573–11578.
DOI: 10.1002/chem.201501987

40 - From the N-Heterocyclic Carbene-Catalyzed Conjugate Addition of Alcohols to the Controlled Polymerization of (Meth)acrylates.
W. Nzahou Ottou, D. Bourichon, J. Vignolle, A.-L. Wirotius, F. Robert, Y. Landais, J.-M. Sotiropoulos, K. Miqueu, D. Taton, Chem. Eur. J. 2015, 21, 9447-9453.
DOI: 10.1002/chem.201500594

39 - Synthesis of New Sulfonyloximes and Their Use in Free-Radical Olefin Carbo-oximation.
B. Ovadia, F. Robert, Y. Landais, Org. Lett. 2015, 17, 1958-1961.
DOI: 10.1021/acs.orglett.5b00672

38 - Base-catalyzed Intramolecular Hydroamination of 1-Substituted Cyclohexa-2,5-dienes. Rationalization of the Mechanism and Application to the Total Synthesis of (+)-epi-Elwesine.
R. Lebeuf, G. Rousseau, K. Schenk, F. Castet, F. Robert, Y. Landais Chem. Eur. J. 2014, 20, 14771–14782.
DOI: 10.1002/chem.201403662

37 - Chiral Polyesters Through Organocatalyzed Step-Growth Polymerization by Desymmetrization of Cyclic Anhydrides.
A. Martin, J. M. Vincent, F. Robert, D. Taton, H. Cramail, Y. Landais Chem. Eur. J. 2014, 20, 11946-11953.
DOI: 10.1002/chem.201402373

36 - Fatty acid-based bis-cyclic carbonates for the synthesis of isocyanate-free poly(hydroxyurethane amide)s
L. Maisonneuve, A. S. More, S. Foltran, C. Alfos, F. Robert, Y. Landais, T. Tassaing, E. Grau, H. Cramail RSC Adv. 2014, 4 , 25795-25803.
DOI: 10.1039/c4ra03675a

35 - Cyclo-dimerization versus polymerization of methyl methacrylate induced by N-heterocyclic carbenes: a combined experimental and theoretical study.
W. Nzahou Ottou, D. Bourichon, J. Vignolle, A.-L. Wirotius, F. Robert, Y. Landais, J.-M. Sotiropoulos, K. Miqueu, D. Taton, Chem. Eur. J. 2014, 20, 3989–3997.
DOI: 10.1002/chem.201304492

34 - One-pot Synthesis and PEGylation of Hyperbranched Polyacetals With a Degree of Branching of 100%.
N. Liu, J. Vignolle, J.-M. Vincent, F. Robert, Y. Landais, H. Cramail, D. Taton, Macromolecules 2014, 47, 1532-1542.
DOI: 10.1021/ma4026509

33 - Polyaldol Synthesis by Direct Organocatalyzed Polymerization of Bis(ketones) and Bis(aldehydes).
N. Liu, A. Martin, F. Robert, J.-M. Vincent, Y. Landais, J. Vignolle, H. Cramail, D. Taton, Macromolecules 2014, 47, 525-533.
DOI: 10.1021/ma402108y

32 - Unexpected Ring contraction of 1-Aryl-cyclohexa-2,5-dienes under Palladium Catalysis.
R. Lebeuf, F. Robert, Y. Landais Arkivoc 2014, Part (III), 6-17. In honor of P. Vogel for his 70th birthday.
Link

31 - Free-radical Carbo-oximation of Olefins and Subsequent Radical-ionic Cascades.
Y. Landais, F. Robert, E. Godineau, L. Huet, N. Likhite Tetrahedron 2013, 69, 10073-10080.
DOI: 10.1016/j.tet.2013.09.051

30 - Organocatalyzed Aldol Reaction Between Pyridine-2-carbaldehydes and a-Ketoacids: A Straightforward Route towards Indolizidines and Isotetronic Acids.
V. Liautard, D. Jardel, C. Davies, M. Berlande, T. Buffeteau, D. Cavagnat, F. Robert, J. M. Vincent, Y. Landais Chem. Eur. J. 2013, 19, 14532-14539.
DOI: 10.1002/chem.201302264

29 - Free-Radical Carbo-alkenylation of Enamides and Ene-carbamates.
C. Poittevin, V. Liautard, R. Beniazza, F. Robert, Y. Landais Org. Lett. 2013, 15, 2814-2817.
DOI: 10.1021/ol401147w

28 - On the chemical fixation of supercritical carbon dioxide with epoxides catalyzed by ionic salts: an in situ FTIR and Raman study.
S. Foltran, J. Alsarraf, F. Robert, Y. Landais, E. Cloutet, H. Cramail, T. Tassaing Catal. Sci. Technol. 2013, 3, 1046-1055.
DOI: 10.1039/C2CY20784B

27 - Latent catalysts based on guanidine templates for polyurethane synthesis.
J. Alsarraf, F. Robert, H. Cramail, Y. Landais Polym. Chem. 2013, 4, 904-907.
DOI: 10.1039/C2PY21006A

26 - Cyclic Guanidines as Efficient Organocatalysts for the Synthesis of Polyurethanes.
J. Alsarraf, Y. Ait Ammar, F. Robert, E. Cloutet, H. Cramail, Y. Landais Macromolecules 2012, 45, 2249-2256.
DOI: 10.1021/ma2026258

25 - Silylboranes as New Sources of Silyl Radicals for Chain-Transfer Reactions.
G. Rouquet, F. Robert, R. Méreau, F. Castet, P. Renaud, Y. Landais Chem. Eur. J. 2012, 18, 940-950.
DOI: 10.1002/chem.201102318

24 - Allylsilanes in “Tin-free” Oximation, Alkenylation, and Allylation of Alkyl Halides.
G. Rouquet, F. Robert, R. Méreau, F. Castet, Y. Landais Chem. Eur. J. 2011, 17, 13904–13911.
DOI: 10.1002/chem.201101842

23 - Free-Radical Carbo-alkynylation and Carbo-alkenylation of Olefins.
V. Liautard, F. Robert, Y. Landais Org. Lett. 2011, 13, 2658–2661.
DOI: 10.1021/ol2007633

22 - An Approach Toward Calystegines and Analogues. Acid-Mediated Migrations of acetates in 7-Membered Ring Systems.
R. Beniazza, V. Desvergnes, G. Mehta, N. Blanchard, F. Robert, Y. Landais J. Org. Chem. 2011, 76, 791-799.
DOI: 10.1021/jo101945h

21 - 4-Alkynoic Acids in the Synthesis of Biologically Important Tetrapyrroles.
Peter A. Jacobi,* Harry L. Brielmann, Melanie Chiu, Indranath Ghosh, Sheila I. Hauck, Sandra Lanz, Sam Leung, Yongkai Li, Hui Liu, Franzisca Löwer, William G. O’Neal, Douglas Pippin, Elizabeth Pollina, Benjamin A. Pratt, Frédéric Robert, William P. Roberts, Carlos Tassa, and Hui Wang Heterocycles 2011, 82, 1029-1081.
DOI: 10.3987/REV-10-SR(E)6

20 - Fragmentation of ß-Silyl Radicals. A Computational Study.
R. Mereau, P. d'Antuono, F. Castet, G. Rouquet, F. Robert, Y. Landais, Organometallics 2010, 29, 2406-2412.
DOI: 10.1021/ol1004627

19 - Straightforward Assembly of the Octahydroisoquinoline Core of Morphinan Alkaloids.
J. Dunet, R. Lebeuf, G. Bose, F. Robert, Y. Landais, Org. Lett. 2010, 12, 2178-2181.
DOI: 10.1021/ol1004627

18 - Synthesis of (1-allylcyclohexa-2,5-dienyl)arenes.
G. Rousseau, F. Robert, Y. Landais, Synthesis 2010, 1223-1228.
DOI: 10.1055/s-0029-1218604

17 - Functionnalization and Rearrangement of Spirocyclohexadienyl oxindoles. Experimental and Theoretical Investigations.
G. Rousseau, F. Robert, Y. Landais Chem. Eur. J. 2009, 15, 11160-11173.
DOI: 10.1002/chem.200901434

16 - Birch reductive alkylation of Biaryls. Scope and Limitations.
R. Lebeuf, J. Dunet, R. Beniazza, D. Ibrahim, G. Bose, F. Robert, Y. Landais J. Org. Chem. 2009, 74, 6469-6478. (Featured Article)
DOI: 10.1021/jo901395m

15 - Preparation of [1-(3-hydroxy-phenyl)-3,5-dimethoxy-cyclohexa-2,5-dienyl]-acetonitrile through Birch reductive alkylation (BRA).
R. Lebeuf, M. Berlande, F. Robert, Y. Landais Org. Synth. 2009, 86, 1-10.

14 - Rearrangement of Spirocyclic Oxindoles with Lithium Amide Bases.
G. Rousseau, F. Robert, K. Schenk, Y. Landais Org. Lett. 2008, 10, 4441-4444.
DOI: 10.1021/ol8016885

13 - Carboazidation of Chiral Allylsilanes. Experimental and Theoretical Investigations.
L. Chabaud, Y. Landais, P. Renaud, F. Robert, F. Castet, M. Lucarini, and K. Schenk Chem. Eur. J. 2008, 14, 2744-2756.
DOI: 10.1002/chem.200701401

12 - Photolabile Arylsilyl group. Application to the Oxidation of C-Si bonds.
S. Werle, F. Robert, H. Bouas-Laurent, Y. Landais, Tetrahedon Lett. 2007, 48, 8909-8913.
DOI: 10.1016/j.tetlet.2007.10.057

11 - Efficient Synthetic Approaches to Aspidosperma Alkaloids.
R. Beniazza, J. Dunet, F. Robert, K. Schenk, Y. Landais, Org. Lett. 2007, 9, 3913-3916.
DOI: 10.1021/ol701493k

10 - Desymmetrization of Cyclohexa-2,5-dienes through a Diastereoselective Protonation-Hydroamination Cascade.
R. Lebeuf, F. Robert, K. Schenk, Y. Landais Org. Lett., 2006, 8, 4755-4758.
DOI: 10.1021/ol0618353

9 - Regioselectivity of Birch Reductive Alkylation of Biaryls.
R. Lebeuf, F. Robert, Y. Landais Org. Lett. 2005, 7, 4557-4560.
DOI: 10.1021/ol051377i

8 - Looking forward : A glance into the future of organic chemistry.
Compain, P. ; Desvergnes, V. ; Ollivier, C. ; Robert, F. ; Suzenet, F. ; Barboiu, M. ; Belmont, P. ; Blériot, Y. ; Bolze, F. ; Bouquillon, S. ; Bourguet, E. ; Braida, B. ; Constantieux, T. ; Désaubry, L. ; Dupont, D. ; Gastaldi, S. ; Jérome, F. ; Legoupy, S. ; Marat, X. ; Migaud, M. ; Moitessier, N. ; Papot, S. ; Péri, F. ; Petit, M. ; Py, S. ; Schulz, E. ; Tranoy-Opalinski, I. ; Vauzeilles, B. ; Vayron, P. ; Vergnes, L. ; Vidal, S. ; Wilmouth, S. New J. Chem. 2006, 30, 823-831.
DOI:10.1039/b601837h

7 - Alchimie futures: Compte rendu de l’expérience ESYOP.
Compain, P. ; Desvergnes, V. ; Ollivier, C. ; Robert, F. ; Suzenet, F. ; Barboiu, M. ; Belmont, P. ; Blériot, Y. ; Bolze, F. ; Bouquillon, S. ; Bourguet, E. ; Braida, B. ; Constantieux, T. ; Désaubry, L. ; Dupont, D. ; Gastaldi, S. ; Jérome, F. ; Legoupy, S. ; Marat, X. ; Migaud, M. ; Moitessier, N. ; Papot, S. ; Péri, F. ; Petit, M. ; Py, S. ; Schulz, E. ; Tranoy-Opalinski, I. ; Vauzeilles, B. ; Vayron, P. ; Vergnes, L. ; Vidal, S. ; Wilmouth, S. Compt. Rendu Acad. Sc. Chimie 2006, 9, 127-140.
DOI:10.1016/j.crci.2005.09.004

6 - Asymmetric Pauson-Khand reaction with chiral, electron-deficient mono- and bis-phosphine ligands.
D. Konya, F. Robert, Y. Gimbert, A. E. Greene Tetrahedron Lett. 2004, 45, 6975-6978.

5 - Theoretical Study of the Regiochemistry-Determining Step of the Pauson-Khand Reaction.
Theodorus J. M de Bruin, Anne Milet, Frédéric Robert, Yves Gimbert, Andrew E. Greene J. Am. Chem. Soc. 2001, 123, 7184-7185.

4 - Regiochemistry in the Pauson-Khand Reaction: Has a Trans Effect Been Overlooked ?
Frédéric Robert, Anne Milet, Yves Gimbert, Denés Konya, Andrew E. Greene J. Am. Chem. Soc. 2001, 123, 5396-5400.

3 - Synthesis and Characterization of New Binuclear Co(0) Complexes with Diphosphinoamine Ligands. A Potential Approach for Asymmetric Pauson-Khand Reactions.
Yves Gimbert, Frédéric Robert, André Durif, Marie-Thérèse Averbuch, Nina Kann, Andrew E. Greene J. Org. Chem. 1999, 64, 3492-3497.

2 - Crystal structure of N,N-bis(diphenylphosphino)-N-((S)-a-methylbenzyl)amine, C32H29NP2.
F. Robert, Y. Gimbert, M.-T. Averbuch-Pouchot, A. E. Greene Z. Kristllogr. – New Cryst. Struct. 2000, 215, 233-236.

1 - Crystal structure of (S)-1-[bis(diphenylphosphino)amino]-2-(methoxymethyl)pyrrolidine, C30H32N2OP2.
F. Robert, Y. Gimbert, M.-T. Averbuch, A. Durif, A. E. Greene Z. Kristllogr. – New Cryst. Struct. 1999, 214, 581-582.

Page Updated on Jan 11, 2017.